A diminution in the size of a cell, tissue, organ, or part.


Denoting the influence of chemical factors secreted by a cell on itself.


Products of living organisms, and the organisms themselves.


A material used for the fabrication of an implantable medical device.

Connective Tissue

The matrix-continuous tissue which binds together and is the support of all the structures of the body. The predominant structural protein comprising the extracellular matrix of connective tissue is collagen.


The process of growth and differentiation of tissues and organs.


Small molecules which are chemically synthesized and well defined, intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease.


The science of the development of the individual during the embryonic stage (2 weeks after fertilization of the ovum to the end of the eighth week) and, by extension, in several or even all preceding and subsequent stages of the life cycle.


Refers to tissues and organs whose function is to secrete into the blood or lymph a substance (e.g., hormone) that has a specific effect on another organ or tissue.


The abnormal multiplication or increase in the number of normal cells in normal arrangement in a tissue.


The enlargement or overgrowth of an organ or part due to an increase in size of its constituent cells.

Medical Device

An implant intended:
1) for use in the cure, mitigation, treatment, or prevention of disease, in man or other animals; and
2) to affect the structure or any function of the body.


Two or more tissues combined to form a larger functional unit.


The solution of orthopedic problems through the regeneration of tissues, using the principles and practices of regenerative medicine.


Denoting influence of one cell on other cells in the vicinity.


The renewal of a tissue or organ at the completion of healing.

Remodeling/ Maintenance/ Turnover

The process by which extracellular matrix is replaced in a process of degradation followed by synthesis.


The formation of scar at a site of injury at the completion of healing. In musculoskeletal tissue, scar comprises fibrous tissue, and in neural tissue, "scar" refers to a neuroma.


An aggregation of similarly specialized cells united in the performance of a particular function. Cells serving the same general function and having the same extracellular matrix.